Hypercalcemia may develop both spontaneously and as a result of androgen therapy in women with disseminated breast carcinoma. If it develops while on this agent, the drug should be discontinued. Caution is required in administering these agents to patients with cardiac, renal or hepatic disease. Cholestatic jaundice is associated with therapeutic use of anabolic and androgenic steroids. Edema may occur occasionally with or without congestive heart failure. Concomitant administration of adrenal steroids or ACTH may add to the edema. In children, anabolic steroid treatment may accelerate bone maturation without producing compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height. The effect on bone maturation should be monitored by assessing bone age of the wrist and hand every six months. This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.
Treatable causes of anorexia and cachexia in patients who are near the end of life include chronic pain, mouth conditions (dryness, mucositis resulting from chemotherapy, and infections such as oral candidiasis or oral herpes), gastrointestinal motility problems (., constipation) and reflux esophagitis. In patients with cancer who are being treated with chemotherapy, radiation therapy and/or medications such as opioids or nonsteroidal anti-inflammatory drugs, an attempt should be made to determine whether anorexia and weight loss are due to mucositis, changes in gastrointestinal motility and nausea as the effects of treatment, rather than progressive disease.
Nandrolone is an anabolic steroid, endocrine-metabolic agent that is FDA approved for the treatment of anemia of chronic renal failure . Common adverse reactions include acne in women and prepubertal boys, female hirsutism , male pattern alopecia in women, gynecomastia in men, diarrhea , nausea , vomiting , insomnia , depression , excitability , atrophy of testis , postpubertal males, erectile dysfunction , erection finding- increased frequency, hypertrophy of clitoris , irregular periods, decreased or increased libido in men or women, priapism , enlargement penis in prepubertal males, testicular hypofunction, deepening in voice in women, drug habituation.