Haldol im long acting

Aripiprazole microsphere long-acting injectable (LAI) is a phase III investigational drug that at press time was being reviewed by the FDA. This formulation appears to be similar to risperidone LAI. The active antipsychotic differs in side effect profile and pharmacokinetics. Because the pharmaceutical science of microsphere construction allows many variations, it is not possible to determine the strengths and weaknesses of aripiprazole LAI compared with risperidone LAI microspheres at this time. The dosing intervals currently under investigation are 14 and 28 days. 3

The dose of Haldol Decanoate 50 or Haldol Decanoate 100 should be expressed in terms of its haloperidol content. The starting dose of haloperidol decanoate should be based on the patient's age, clinical history, physical condition, and response to previous antipsychotic therapy. The preferred approach to determining the minimum effective dose is to begin with lower initial doses and to adjust the dose upward as needed. For patients previously maintained on low doses of antipsychotics (. up to the equivalent of 10 mg/day oral haloperidol), it is recommended that the initial dose of haloperidol decanoate be 10–15 times the previous daily dose in oral haloperidol equivalents; limited clinical experience suggests that lower initial doses may be adequate.

The intravenous route is not FDA approved and is generally not recommended except when no other alternatives are available. Intravenous administration appears to be associated with a higher risk of QT prolongation and torsade de pointes (TdP) than other forms of administration. The manufacturer recommends ECG monitoring for QT prolongation and arrhythmias if IV administration is required. A dose in the range of 1 to 5 mg IV has been suggested, with the dose being repeated at 30 to 60 minute intervals, if needed. A maximum IV dose has not been established. The lowest effective dose should be used in conjunction with conversion to oral therapy as soon as possible.

Nitschke and Stewart 3 state that the oral form of Nembutal sold in 100ml bottles (sterile bottles) at a concentration of 60mg per ml (. 6 grams in a bottle) is enough to provide a peaceful death, although in some cases this can take up to 24 hours. For powdered Chinese Nembutal which is sold in higher quantities, 10grams dissolved in 50ml of water is suggested, and forum posts suggest this is a more reliable dose whilst also being easier to ingest. They recommend ceasing any other medications a few days before taking Nembutal. There is also non-sterile (green coloured) Nembutal that is concentrated 300mg per ml, in which case a 50ml sample equates to 15 grams, and is more than enough for a peaceful death. Compassion in Dying 5 recommend 6g - 9g of Nembutal. Dignitas use 15 grams of a concentrated soluble form of Nembutal that can be swallowed in a few mouthfuls. 3, 6

Haloperidol is a typical butyrophenone type antipsychotic that exhibits high affinity dopamine D 2 receptor antagonism and slow receptor dissociation kinetics. [42] It has effects similar to the phenothiazines . [17] The drug binds preferentially to D 2 and α 1 receptors at low dose (ED 50 = and  mg/kg, respectively), and 5-HT 2 receptors at a higher dose (ED 50 =  mg/kg). Given that antagonism of D 2 receptors is more beneficial on the positive symptoms of schizophrenia and antagonism of 5-HT 2 receptors on the negative symptoms, this characteristic underlies haloperidol's greater effect on delusions, hallucinations and other manifestations of psychosis. [43] Haloperidol's negligible affinity for histamine H 1 receptors and muscarinic M 1 acetylcholine receptors yields an antipsychotic with a lower incidence of sedation, weight gain, and orthostatic hypotension though having higher rates of treatment emergent extrapyramidal symptoms .

Haldol im long acting

haldol im long acting

Nitschke and Stewart 3 state that the oral form of Nembutal sold in 100ml bottles (sterile bottles) at a concentration of 60mg per ml (. 6 grams in a bottle) is enough to provide a peaceful death, although in some cases this can take up to 24 hours. For powdered Chinese Nembutal which is sold in higher quantities, 10grams dissolved in 50ml of water is suggested, and forum posts suggest this is a more reliable dose whilst also being easier to ingest. They recommend ceasing any other medications a few days before taking Nembutal. There is also non-sterile (green coloured) Nembutal that is concentrated 300mg per ml, in which case a 50ml sample equates to 15 grams, and is more than enough for a peaceful death. Compassion in Dying 5 recommend 6g - 9g of Nembutal. Dignitas use 15 grams of a concentrated soluble form of Nembutal that can be swallowed in a few mouthfuls. 3, 6

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