Some states cited very few antipsychotic drug deficiencies, and other states, larger numbers. One state cited only eight antipsychotic drug deficiencies in the two-year period; another state cited 148 antipsychotic drug deficiencies. These differences are not explained by the number of facilities in the states.  The lowest-citing state cited one antipsychotic drug deficiency for every nursing facilities in the two-year period; the highest-citing state cited one antipsychotic drug deficiency for every nursing facilities in the two-year period.
Haloperidol is a typical butyrophenone type antipsychotic that exhibits high affinity dopamine D 2 receptor antagonism and slow receptor dissociation kinetics.  It has effects similar to the phenothiazines .  The drug binds preferentially to D 2 and α 1 receptors at low dose (ED 50 = and mg/kg, respectively), and 5-HT 2 receptors at a higher dose (ED 50 = mg/kg). Given that antagonism of D 2 receptors is more beneficial on the positive symptoms of schizophrenia and antagonism of 5-HT 2 receptors on the negative symptoms, this characteristic underlies haloperidol's greater effect on delusions, hallucinations and other manifestations of psychosis.  Haloperidol's negligible affinity for histamine H 1 receptors and muscarinic M 1 acetylcholine receptors yields an antipsychotic with a lower incidence of sedation, weight gain, and orthostatic hypotension though having higher rates of treatment emergent extrapyramidal symptoms .