Equipoise clinical trial

Miller and Brody argue that the notion of clinical equipoise is fundamentally misguided. The ethics of therapy and the ethics of research are two distinct enterprises that are governed by different norms. They state, “The doctrine of clinical equipoise is intended to act as a bridge between therapy and research, allegedly making it possible to conduct RCTs without sacrificing the therapeutic obligation of physicians to provide treatment according to a scientifically validated standard of care. This constitutes therapeutic misconception concerning the ethics of clinical trials, analogous to the tendency of patient volunteers to confuse treatment in the context of RCTs with routine medical care.” [5] Equipoise, they argue, only makes sense as a normative assumption for clinical trials if one assumes that researchers have therapeutic obligations to their research participants. Further criticisms of clinical equipoise have been leveled by Robert Veatch [6] and by Peter Ubel and Robert Silbergleit. [7]

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  • Citation tools Download this article to citation manager Moher David , Hopewell Sally , Schulz Kenneth F , Montori Victor , Gøtzsche Peter C , Devereaux P J et al. CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials BMJ 2010; 340 :c869
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  • Citation tools Download this article to citation manager Furler John , O’Neal David , Speight Jane , Manski-Nankervis Jo-Anne , Gorelik Alexandra , Holmes-Truscott Elizabeth et al. Supporting insulin initiation in type 2 diabetes in primary care: results of the Stepping Up pragmatic cluster randomised controlled clinical trial BMJ 2017; 356 :j783
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    Equipoise clinical trial

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